Malignant Hyperthermia Essay -- Medical Biology Disease

Malignant HyperthermiaAbstractA patient, waiting to undergo his cardiac surgery, is imposition on a surgical platform. Ananesthesiologist enters the surgical room and injects some general anesthetics into thepatients bloodstream. The patient appears normal until after a fewer minutes, the patientsuddenly experiences increasing body temperatures leading to a high fever, musclerigidity, and increased heart rate. The anesthesiologist is perturbed, runs out of thesurgery room, and alerts the surgical module of the patients alarming symptoms. Thesurgical staff identifies the symptoms as Malignant Hyperthermia. What exactly isMalignant Hyperthermia and how is it caused? Malignant Hyperthermia, a rare skeletal knock-down(a) disease found in humans, pigs, horses, and many other animals, is achannelopathy caused by abnormal calcium channels. This paper serves to investigate theproblems within the specific ion channels know to cause the disease. The goal of thepaper is to understand more ab out Malignant Hyperthermia and about how particular ionchannels associated with the disease operate. Learning about the interpersonal chemistry behind thedisease is crucial in order to prevent future occurrences of Malignant Hyperthermia andto design new treatments.IntroductionMalignant hyperthermia is a fatal, inherited disorder that affects less than 200,000people in the United States. 1 As mentioned in the abstract, Malignant Hyperthermia ischannelopathy, or a disease caused by mutations in channel protein genes. MalignantHyperthermia is triggered by anesthetics, which includes common inhalants, and bymedication containing succinylcholine, a substance often used as a muscle relaxant inemergency medicines. 2 After the initial ... ...anodine receptor-Ca2+ release channels inmalignant hyperthermia. Biophys J. 73(4) Oct 1997 29. Jul 2008.8 Jiang, Dawei, Wenqian Chen1, Jianmin Xiao, Ruiwu Wang, Huihui Kong, Peter P.Jones, Lin Zhang, Bradley Fruen, and S. R. Wayne Chen. Reduced Thresh old forLuminal Ca2+ Activation of RyR1 Underlies a causative Mechanism of Porcine MalignantHyperthermia. J. Biol. Chem. Vol. 283, Issue 3025 July 2008. 29 Jul 2008.9 Korf, Bruce R. Korf Genetics. Human Genetics and Genomics . BlackwellPublishing. 29 Jul 2008.10 Millar, 2007. Cerebrospinal Fluid Research. 29 Jul 2008.